The vulnerabilities of cancer at the cellular and, recently, with the introduction of
immunotherapy, at the tissue level, have been exploited with variable success. Evaluating …

The era of targeted cancer therapies has arrived. However, due to the complexity of
biological systems, the current progress is far from enough. From biological network …

Integromics is necessitated as the complex diseases require to collate the integrated
analysis expression, variation, and regulation of genes involved in trigger, prognosis, and …

This perspective article gathers the latest developments in mathematical and computational
oncology tools that exploit network approaches for the mathematical modelling, analysis …

Background Resistance to therapy remains a major cause of the failure of cancer treatment.
A major challenge in cancer therapy is to design treatment strategies that circumvent the …

Cancer is increasingly described as a systems-level, network phenomenon. Genetic
methods, such as next generation sequencing and RNA interference uncovered the …

There is a widening recognition that cancer cells are products of complex developmental
processes. Carcinogenesis and metastasis formation are increasingly described as systems …

Over the past decade, solid tumors have increasingly become recognized as discrete
'organs' that show a complexity that approaches and may even exceed that of normal …

Solid cancers are not simple accumulations of malignant tumor cells but rather represent
complex organ-like structures. Despite a more chaotic general appearance as compared to …

Polypharmacology has emerged as novel means in drug discovery for improving treatment
response in clinical use. However, to really capitalize on the polypharmacological effects of …