Hantaviruses, Escapees from the Death Row: Viral Mechanisms Towards Apoptosis Resistance

CS Riera - 2019 - search.proquest.com
Over the past decades, humanity has witnessed a constant stream of emerging pathogenic
RNA viruses. The recurrent outbreaks of Ebola virus in Africa, the emergence of West Nile …

Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells

A Markotic, L Hensley, T Geisbert… - Journal of general …, 2003 - microbiologyresearch.org
Hantaviruses are maintained in nature in persistently infected rodents and can also
persistently infect cultured mammalian cells, causing little or no cytopathology. An …

Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2

C Solà-Riera, M García, HG Ljunggren… - PLoS …, 2020 - journals.plos.org
Hantaviruses, zoonotic RNA viruses belonging to the order Bunyavirales, cause two severe
acute diseases in humans, hemorrhagic fever with renal syndrome (HFRS) and hantavirus …

Hantavirus inhibits TRAIL-mediated killing of infected cells by downregulating death receptor 5

C Solà-Riera, S Gupta, KT Maleki… - Cell reports, 2019 - cell.com
Cytotoxic lymphocytes normally kill virus-infected cells by apoptosis induction. Cytotoxic
granule-dependent apoptosis induction engages the intrinsic apoptosis pathway, whereas …

[PDF][PDF] How hantaviruses modulate cellular pathways for efficient replication

IT Hussein, MA Mir - Front Biosci (Elite Ed), 2013 - article.imrpress.com
Introduction 3. Modulation of the innate immune response 3.1. Cytoplasmic tail of Gn protein
3.2. Non-structural protein 3.3. Nucleocapsid protein 4. Modulation of the host mRNA …

Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis

K Davies, B Afrough, J Mankouri… - Journal of General …, 2019 - microbiologyresearch.org
The family Hantaviridae mostly comprises rodent-borne segmented negative-sense RNA
viruses, many of which are capable of causing devastating disease in humans. In contrast …

[PDF][PDF] Cellular mechanisms of hantavirus-induced apoptosis

XD Li - 2005 - helda.helsinki.fi
In recent years hantaviruses have emerged as important human pathogens and attracted
great public attention worldwide. Hantaviruses are maintained in their rodent reservoirs as …

Pathogenic and non-pathogenic hantaviruses use different apoptotic pathways

M Janković, M Bego, L Cebalo, S St Jeor… - … Conference on HFRS …, 2007 - croris.hr
Sažetak Hantaviruses are maintained in nature in persistently infected rodents and can also
persistently infect cultured mammalian cells, causing little or no cytopathology. An …

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis

S Gupta, M Braun, ND Tischler, M Stoltz… - PLoS …, 2013 - journals.plos.org
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardio-
pulmonary syndrome (HCPS; also called hantavirus pulmonary syndrome (HPS)), both …

Viruses run: the evasion mechanisms of the antiviral innate immunity by hantavirus

Y Zhang, R Ma, Y Wang, W Sun, Z Yang… - Frontiers in …, 2021 - frontiersin.org
Hantavirus can cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and
hantavirus pulmonary syndrome (HPS) in America, with high mortality and unknown …