Cytokine storm and mucus hypersecretion in COVID-19: review of mechanisms

MA Khan, ZA Khan, M Charles, P Pratap… - Journal of …, 2021 - Taylor & Francis
Mucus is an integral part of the respiratory physiology. It protects the respiratory tract by
acting as a physical barrier against inhaled particles and microbes. Excessive inflammation …

[HTML][HTML] Abnormal airway mucus secretion induced by virus infection

Y Li, XX Tang - Frontiers in immunology, 2021 - frontiersin.org
The airway mucus barrier is a primary defensive layer at the airway surface. Mucins are the
major structural components of airway mucus that protect the respiratory tract. Respiratory …

Mucus targeting as a plausible approach to improve lung function in COVID-19 patients

SS Kumar, A Binu, AR Devan, LR Nath - Medical Hypotheses, 2021 - Elsevier
Abstract COVID-19 (SARS-CoV-2) has emerged as one of the worst pandemics that have
tormented the globe due to its highly contagious nature. Even if the disease manifests fever …

Prevalence and mechanisms of mucus accumulation in COVID-19 lung disease

T Kato, T Asakura, CE Edwards, H Dang… - American journal of …, 2022 - atsjournals.org
Rationale: The incidence and sites of mucus accumulation and molecular regulation of
mucin gene expression in coronavirus (COVID-19) lung disease have not been reported …

Influence of SARS-CoV-2 on airway mucus production: A review and proposed model

DK Meyerholz, LR Reznikov - Veterinary pathology, 2022 - journals.sagepub.com
Coronavirus disease 2019 (COVID-19) is a worldwide pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) that has affected millions of lives …

[HTML][HTML] Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19

Y Liu, J Lv, J Liu, M Li, J Xie, Q Lv, W Deng, N Zhou… - Cell Research, 2020 - nature.com
Silent hypoxia has emerged as a unique feature of coronavirus disease 2019 (COVID-19). In
this study, we show that mucins are accumulated in the bronchoalveolar lavage fluid (BALF) …

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
The lung is a key target of the cytokine storm that can be triggered by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical …

[HTML][HTML] Cytokine storm in COVID-19:“when you come out of the storm, you won't be the same person who walked in”

V Castelli, A Cimini, C Ferri - Frontiers in immunology, 2020 - frontiersin.org
In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent
of a severe respiratory infection named SARS-CoV-2, and it has since been recognized …

[HTML][HTML] Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID‐19 patients

W Lu, X Liu, T Wang, F Liu, A Zhu, Y Lin… - Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Patients with coronavirus disease 2019 (COVID‐19) exhibit a spectrum of respiratory
symptoms like cough and dyspnea. 1‐3 Airway mucus is an adhesive viscoelastic gel …

Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications

R Hirawat, MA Saifi, C Godugu - Life sciences, 2021 - Elsevier
Such testing and trying time probably never seen before in the human history. The novel
coronavirus disease abbreviated as COVID-19 is the ongoing health crisis which entered …