The house mouse, Mus musculus, is an exceptional model system, combining genetic
tractability with close homology to human biology. Gestation in mouse development lasts …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Cellular responses to stimuli are rapid and continuous and yet the vast majority of
investigations of transcriptional responses during developmental transitions typically use …

INTRODUCTION Metazoan development represents a big jump in complexity compared
with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …

Differential gene expression is a prerequisite for the formation of multiple cell types from the
fertilized egg during embryogenesis. Understanding the gene regulatory networks …

Mouse embryonic development is a canonical model system for studying mammalian cell
fate acquisition. Recently, single-cell atlases comprehensively charted embryonic …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4-to 6-week human embryos when …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Biomedical research relies heavily on the use of model organisms to gain insight into human
health and development. Traditionally, the mouse has been the favored vertebrate model …