Rationale: The success of cardiac stem cell therapies is limited by low cell retention, due at
least in part to washout via coronary veins. Objective: We sought to counter the efflux of …

The efficiency of stem cell transplantation is limited by low cell retention. Intracoronary (IC)
delivery is convenient and widely used but exhibits particularly low cell retention rates. We …

Stem cell transplantation is a promising therapeutic strategy for acute or chronic ischemic
cardiomyopathy. A major limitation to efficacy in cell transplantation is the low efficiency of …

Introduction Retrograde coronary venous infusion is a promising delivery method for cellular
cardiomyoplasty. Poor cell retention is the major obstacle to the establishment of this method …

Stem cells offer a promising approach to the treatment of myocardial infarction and
prevention of heart failure. We have used iron labeling of bone marrow stromal cells …

Cell replacement in the heart is considered a promising strategy for the treatment of post-
infarct heart failure. Direct intramyocardial injection of cells proved to be the most effective …

Advances in the biology of stem cells have evoked great interest in cell replacement
therapies for the regeneration of heart tissue after myocardial infarction. However, results …

Background—Delivery and tracking of endomyocardial stem cells are limited by the inability
to image transplanted cells noninvasively in the beating heart. We hypothesized that …

Background—Cell labeling with superparamagnetic iron oxide (SPIO) nanoparticles
enables noninvasive MRI and tracking of transplanted stem cells. We sought to determine …

OBJECTIVES: Cell therapy improved cardiac function after a myocardial infarction in several
preclinical studies; however, the functional benefits were limited in the initial clinical trials …