Amino acid metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics …

L Ansone, M Briviba, I Silamikelis… - Microbiology …, 2021 - Am Soc Microbiol
The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for
early molecular characterization of patients followed by risk-stratified care. The main …

Metabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation

FC Ceballos, A Virseda-Berdices, S Resino… - Frontiers in …, 2022 - frontiersin.org
Background metabolic changes through SARS-CoV-2 infection has been reported but not
fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 …

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

H Blasco, C Bessy, L Plantier, A Lefevre, E Piver… - Scientific reports, 2020 - nature.com
The biological mechanisms involved in SARS-CoV-2 infection are only partially understood.
Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search …

Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and …

JC Páez-Franco, JL Maravillas-Montero… - PLoS …, 2022 - journals.plos.org
It is well known that the presence of comorbidities and age-related health issues may hide
biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases …

Longitudinal metabolomics reveals ornithine cycle dysregulation correlates with inflammation and coagulation in COVID-19 severe patients

T Li, N Ning, B Li, D Luo, E Qin, W Yu, J Wang… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is a severe disease in humans, as highlighted by the current global pandemic.
Several studies about the metabolome of COVID-19 patients have revealed metabolic …

Disturbed lipid and amino acid metabolisms in COVID-19 patients

M Masoodi, M Peschka, S Schmiedel… - Journal of molecular …, 2022 - Springer
Abstract The Coronavirus disease 2019 (COVID-19) pandemic is overwhelming the
healthcare systems. Identification of systemic reactions underlying COVID-19 will lead to …

Biological and clinical factors contributing to the metabolic heterogeneity of hospitalized patients with and without COVID-19

A D'alessandro, T Thomas, IJ Akpan, JA Reisz… - Cells, 2021 - mdpi.com
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide
challenge. The present large study sought to understand independent and overlapping …

Metabolic signatures associated with severity in hospitalized COVID-19 patients

J Marín-Corral, J Rodríguez-Morató… - International journal of …, 2021 - mdpi.com
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the
metabolic pathways that are altered early with viral infection and their association with …

Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

FX Danlos, C Grajeda-Iglesias, S Durand… - Cell Death & …, 2021 - nature.com
The circulating metabolome provides a snapshot of the physiological state of the organism
responding to pathogenic challenges. Here we report alterations in the plasma metabolome …

Metabolomics study of COVID-19 patients in four different clinical stages

A Valdés, LO Moreno, SR Rello, A Orduña… - Scientific reports, 2022 - nature.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the coronavirus
strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To …