Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in
several preclinical models of autoimmunity and B cell malignancies. Despite these …

The uniqueness of MALT1 protease activity in controlling several aspects of immunity in
humans has made it a very attractive therapeutic target for multiple autoimmune diseases …

MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-
κB and other key signaling pathways in different cell types. Activities of MALT1 are mediated …

The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in
autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 …

MALT1 forms part of a central signaling node downstream of immunoreceptor tyrosine-
based activation motif (ITAM)-containing receptors, across a broad range of immune cell …

The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of
multiple receptors in both immune and nonimmune cells. Genetic disruption of Malt1 …

Mucosa‐associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating
the activation of nuclear factor κB (NF‐κB) signaling through both its adaptor and proteolytic …

The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1
(MALT1) regulates nuclear-factor-kappa-B (NF-κB) activation downstream of surface …

Background The paracaspase mucosa-associated lymphoid tissue lymphoma translocation
protein 1 (MALT1) is crucial for lymphocyte activation through signaling to the transcription …

CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and
other pathways. Previous studies have suggested that as part of this complex, MALT1 …