Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines

J Zhou, Z Liu, G Zhang, W Xu, L Xing… - Journal of Medical …, 2023 - Wiley Online Library
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
variants with high transmission rates and striking immune evasion have posed a serious …

Pan-sarbecovirus neutralizing antibodies in BNT162b2-immunized SARS-CoV-1 survivors

CW Tan, WN Chia, BE Young, F Zhu… - … England Journal of …, 2021 - Mass Medical Soc
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of
concern pose a challenge to the effectiveness of current vaccines. A vaccine that could …

A bivalent vaccine containing D614G and BA. 1 spike trimer proteins or a BA. 1 spike trimer protein booster shows broad neutralizing immunity

P Du, N Li, X Xiong, S Tang, Q Dai, Z Liu… - Journal of medical …, 2022 - Wiley Online Library
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
Omicron variant, sublineages BA. 1 and BA. 2, recently became the dominant variants of …

Heterologous boosting with third dose of coronavirus disease recombinant subunit vaccine increases neutralizing antibodies and T cell immunity against different …

Z Zhao, T Cui, M Huang, S Liu, X Su, G Li… - Emerging microbes & …, 2022 - Taylor & Francis
Waned vaccine-induced immunity and emerging severe acute respiratory syndrome
coronavirus 2 variants with potential for immune escape pose a major threat to the …

Serosurvey in SARS‐CoV‐2 inactivated vaccine‐elicited neutralizing antibodies against authentic SARS‐CoV‐2 and its viral variants

L Zou, H Zhang, Z Zheng, Y Jiang… - Journal of Medical …, 2022 - Wiley Online Library
Various variants of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
have been emerging and circulating in different parts of the world. Millions of vaccine doses …

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

W He, R Musharrafieh, G Song, K Dueker, LV Tse… - Nature …, 2022 - nature.com
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

P Wang, RG Casner, MS Nair, J Yu, Y Guo… - Emerging microbes & …, 2022 - Taylor & Francis
The repeated emergence of highly pathogenic human coronaviruses as well as their
evolving variants highlight the need to develop potent and broad-spectrum antiviral …

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

Y Cao, F Jian, Z Zhang, A Yisimayi, X Hao, L Bao… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages have
escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies …

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Z Liu, J Zhou, W Xu, W Deng, Y Wang, M Wang… - Cell research, 2022 - nature.com
The emergence of SARS-CoV-2 variants and potentially other highly pathogenic
sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we …

Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses

PJ Halfmann, SJ Frey, K Loeffler, M Kuroda… - …, 2022 - thelancet.com
Background The COVID-19 pandemic continues to cause morbidity and mortality worldwide.
Most approved COVID-19 vaccines generate a neutralizing antibody response that primarily …