Autoimmunity and immunodeficiency were previously considered to be mutually exclusive
conditions; however, increased understanding of the complex immune regulatory and …

Human primary immunodeficiency diseases are experiments of nature characterized by an
increased susceptibility to infection. In many cases, they are also associated with …

Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune
system and represent 2 sides of the same coin. Multiple single-gene defects have been …

The realization that primary immunodeficiencies can also impair negative regulation of
immune responses has provided a new framework for the understanding of autoimmunity …

The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

Advances in DNA sequencing technologies have led to a quickening in the pace at which
new genetic immunodeficiency disorders have been identified. Among the newly identified …

Recent evidence suggests that systemic autoimmunity and immunodeficiency are not
separate entities, but rather are interconnected processes. Immunodeficiency results from …

During the last years, studies investigating the intriguing association between
immunodeficiency and autoimmunity led to the discovery of new monogenic disorders, the …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

Progress in defining the genetics of autoimmune disease has been dramatically enhanced
by large scale genetic studies. Genome-wide approaches, examining hundreds or for some …