Many sensory systems in cells and organisms share a recurring property called fold-change
detection (FCD). FCD describes a system whose dynamics–including amplitude and …

Two central biophysical laws describe sensory responses to input signals. One is a
logarithmic relationship between input and output, and the other is a power law relationship …

Evolution repeatedly converges on only a few regulatory circuit designs that achieve a given
function. This simplicity helps us understand biological networks. However, why so few …

Many sensory systems (eg, vision and hearing) show a response that is proportional to the
fold-change in the stimulus relative to the background, a feature related to Weber's Law …

Recent studies suggest that certain cellular sensory systems display fold-change detection
(FCD): a response whose entire shape, including amplitude and duration, depends only on …

Biology emerges from interactions between molecules, which are challenging to elucidate
with current techniques. An orthogonal approach is to probe for'response signatures' that …

A recurring theme in biological circuits is the existence of components that are
antagonistically bifunctional, in the sense that they simultaneously have two opposing …

Biological organisms use their sensory systems to detect changes in their environment. The
ability of sensory systems to adapt to static inputs allows wide dynamic range as well as …

Many sensory systems, from vision and hearing in animals to signal transduction in cells,
respond to fold changes in signal relative to background. Responding to fold change …

Sensory systems rescale their response sensitivity upon adaptation according to simple
strategies that recur in processes as diverse as single-cell signaling, neural network …