Genetics of rheumatoid arthritis: 2018 status

Y Okada, S Eyre, A Suzuki, Y Kochi… - Annals of the rheumatic …, 2019 - ard.bmj.com
Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the
discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci …

Update on the genetic architecture of rheumatoid arthritis

K Kim, SY Bang, HS Lee, SC Bae - Nature Reviews Rheumatology, 2017 - nature.com
Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic
loci associated with susceptibility to RA and have refined the RA-association model for HLA …

Meta‐analysis of four rheumatoid arthritis genome‐wide linkage studies: confirmation of a susceptibility locus on chromosome 16

SA Fisher, JS Lanchbury, CM Lewis - Arthritis & Rheumatism, 2003 - Wiley Online Library
Objective Susceptibility to rheumatoid arthritis (RA) is likely to involve several genes of weak
effect, and consequently, individual studies may have insufficient power to detect linkage …

Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families

D Jawaheer, MF Seldin, CI Amos… - … : Official Journal of …, 2003 - Wiley Online Library
Objective A number of non‐HLA loci that have shown evidence (P< 0.05) for linkage with
rheumatoid arthritis (RA) have been previously identified. The present study attempts to …

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

K Ishigaki, S Sakaue, C Terao, Y Luo, K Sonehara… - Nature …, 2022 - nature.com
Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-
ancestry genetic research of RA promises to improve power to detect genetic signals, fine …

Rheumatoid arthritis: a view of the current genetic landscape

MJH Coenen, PK Gregersen - Genes & Immunity, 2009 - nature.com
The field of genetics and autoimmune diseases is undergoing a rapid and unprecedented
expansion with new genetic findings being reported at an astounding pace. It is now clear …

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

D Plant, E Flynn, H Mbarek, P Dieudé… - Annals of the …, 2010 - ard.bmj.com
Background Genetic factors have a substantial role in determining development of
rheumatoid arthritis (RA), and are likely to account for 50–60% of disease susceptibility …

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 …

E Ha, SC Bae, K Kim - Annals of the rheumatic diseases, 2021 - ard.bmj.com
Objectives Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes
have been identified by population-based genetic association studies, suggesting a large …

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

S Saevarsdottir, L Stefansdottir, P Sulem… - Annals of the …, 2022 - ard.bmj.com
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or
ACPA positive) and seronegative subsets. Methods We performed a genome-wide …

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis

D Diogo, F Kurreeman, EA Stahl, KP Liao… - The American Journal of …, 2013 - cell.com
The extent to which variants in the protein-coding sequence of genes contribute to risk of
rheumatoid arthritis (RA) is unknown. In this study, we addressed this issue by deep exon …