The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing
injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the …

GPRC6A is a widely expressed orphan G protein–coupled receptor that senses extracellular
amino acids, osteocalcin, and divalent cations in vitro. GPRC6A null (GPRC6A−/−) mice …

Regulator of G protein signaling (RGS) proteins are critical negative molecules of G protein-
coupled receptor (GPCR) signaling, which mediates a variety of biological processes in …

G protein–coupled receptors (GPCRs) play a key role in regulating bone remodeling.
Whether GPCRs exert anabolic or catabolic osseous effects may be determined by the rate …

G protein-coupled receptors (GPCRs) coupled to activation of Gs, such as the PTH1 receptor
(PTH1R), have long been known to regulate skeletal function and homeostasis. However …

G-protein-coupled receptor (GPCR) 48 (Gpr48; Lgr4), a newly discovered member of the
glycoprotein hormone receptor subfamily of GPCRs, is an orphan GPCR of unknown …

Heterotrimeric G proteins couple seven-transmembrane receptors for diverse extracellular
signals to effectors that generate intracellular signals altering cell function. Mutations in the …

Background GPRC6A is a widely expressed orphan G-protein coupled receptor that senses
extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological …

GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of La-
amino acids, a signaling augmented by the divalent cations Ca2C and Mg2C. GPRC6A …