RIG-I recognizes viral dsRNA and activates a cell-autonomous antiviral response. Upon
stimulation, it triggers a signaling cascade leading to the production of type I and III IFNs …

Innate immunity is the first line of defense against invading pathogens. Rapid and efficient
detection of pathogen-associated molecular patterns via pattern-recognition receptors is …

Recognition of viral pathogens by the retinoic acid-inducible gene I (RIG-I)-like receptor
(RLR) family results in the activation of type I interferon (IFN) responses. To avoid this …

RIG-I is essential for host defense against viral pathogens, as it triggers the release of type I
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …

The activation of retinoic acid–inducible gene I (RIG-I), an indispensable viral RNA sensor in
mammals, is subtly regulated by ubiquitination. Although multiple ubiquitination sites at the …

The RIG-I-like receptor (RLR) pathway is essential for detecting cytosolic viral RNA to trigger
the production of type I interferons (IFNα/β) that initiate an innate antiviral response. Through …

RIG-I-like receptors (RLRs) are cytoplasmic sensors of viral RNA that trigger the signaling
cascade that leads to type I interferon (IFN) production. Transcriptional induction of RLRs by …

RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an
antiviral signaling that induces the production of interferons and proinflammatory cytokines …

Recognition of invading viruses by the host is elicited by cellular sensors which trigger
signaling cascades that lead to type I interferon (IFN) gene expression. Retinoic acid …

Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5′-triphosphorylated RNA and
triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent …