Pharmacology of heparin and related drugs: An update

J Hogwood, B Mulloy, R Lever, E Gray, CP Page - Pharmacological reviews, 2023 - ASPET
Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Heparin: An old drug for new clinical applications

P Wang, L Chi, Z Zhang, H Zhao, F Zhang… - Carbohydrate …, 2022 - Elsevier
Heparin, an old but first-line anticoagulant, has been used over a century. It is a
heterogeneous, linear, highly sulfated, anionic glycosaminoglycan with a broad distribution …

Using heparin molecules to manage COVID‐2019

J Liu, J Li, K Arnold, R Pawlinski… - Research and practice …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is becoming one of the
largest global public health crises in modern history. The race for an effective drug to prevent …

Comprehensive landscape of heparin therapy for COVID-19

C Shi, W Tingting, JP Li, MA Sullivan, C Wang… - Carbohydrate …, 2021 - Elsevier
The pandemic coronavirus disease 2019 (COVID-19), caused by the infection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading globally …

Heparin as a therapy for COVID-19: current evidence and future possibilities

JA Hippensteel, WB LaRiviere… - … of Physiology-Lung …, 2020 - journals.physiology.org
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every …

Heparin–an old drug with multiple potential targets in Covid‐19 therapy

U Lindahl, JP Li - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
2. Dianne K, Jennings I, Kitchen S, Walker I. Letter in response to article “Systematic review
of viscoelastic testing (TEG/Rotem) in obstetrics and recommendations from the women's …

[HTML][HTML] Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

C Conzelmann, JA Müller, L Perkhofer, KMJ Sparrer… - Clinical Medicine, 2020 - Elsevier
Here, we advocate a highly favourable opportunity for the treatment of COVID-19 disease by
repurposing a long-serving medical agent with an excellent history of clinical use, namely …

Low molecular weight heparin, anti-inflammatory/immunoregulatory and antiviral effects, a short update

A Vitiello, F Ferrara - Cardiovascular Drugs and Therapy, 2023 - Springer
Low molecular weight heparin (LMWH) is a glycosaminoglycan long known for its
anticoagulant properties. In recent times, recent evidence has associated this drug with extra …

[HTML][HTML] Pharmacological and clinical application of heparin progress: An essential drug for modern medicine

M Qiu, S Huang, C Luo, Z Wu, B Liang, H Huang… - Biomedicine & …, 2021 - Elsevier
Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is
still used in a variety of clinical indications. Since it was discovered in 1916, after more than …

Use of enoxaparin to counteract COVID-19 infection and reduce thromboembolic venous complications: a review of the current evidence

F Drago, L Gozzo, L Li, A Stella, B Cosmi - Frontiers in pharmacology, 2020 - frontiersin.org
The impact of the COVID-19 pandemic has been dramatic worldwide, with China, Italy, and
now US at its epicenter. Researchers and clinicians are studying and testing different …