APOE genotype and sex modulate Alzheimer's disease pathology in aged EFAD transgenic mice
D Balu, AC Valencia-Olvera, Z Islam… - Frontiers in Aging …, 2023 - frontiersin.org
Increasing evidence supports that age, APOE and sex interact to modulate Alzheimer's
disease (AD) risk, however the underlying pathways are unclear. One way that AD risk …
disease (AD) risk, however the underlying pathways are unclear. One way that AD risk …
Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer's disease
Age, genetics, and chromosomal sex have been identified as critical risk factors for late-
onset Alzheimer's disease (LOAD). The predominant genetic risk factor for LOAD is the …
onset Alzheimer's disease (LOAD). The predominant genetic risk factor for LOAD is the …
The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha
LR Taxier, SM Philippi, JM York, MJ LaDu… - Neurobiology of aging, 2022 - Elsevier
Women carriers of APOE4, the greatest genetic risk factor for late-onset Alzheimer's disease
(AD), are at highest risk of developing AD, yet factors underlying interactions between …
(AD), are at highest risk of developing AD, yet factors underlying interactions between …
EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimerʼns disease [S]
LM Tai, D Balu, E Avila-Munoz, L Abdullah… - Journal of lipid …, 2017 - ASBMB
Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimerʼns
disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing …
disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing …
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
D Liu, X Pan, J Zhang, H Shen, NC Collins… - Molecular …, 2015 - Springer
Background Alzheimer's disease (AD) causes progressive loss of memory and cognition,
exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism for …
exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism for …
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease
KL Youmans, LM Tai, E Nwabuisi-Heath… - Journal of Biological …, 2012 - ASBMB
APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with
amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ …
amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ …
Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice
RC Klein, SK Acheson, BE Mace, PM Sullivan… - Neurobiology of …, 2014 - Elsevier
The human APOE4 allele is associated with an early age of onset and increased risk of
Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein …
Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein …
Apolipoprotein E4 causes age-and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice
L Leung, Y Andrews-Zwilling, SY Yoon, S Jain, K Ring… - PloS one, 2012 - journals.plos.org
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD). ApoE4
has sex-dependent effects, whereby the risk of developing AD is higher in apoE4 …
has sex-dependent effects, whereby the risk of developing AD is higher in apoE4 …
APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer's disease mice
TL Stephen, B Breningstall, S Suresh, CJ McGill… - Journal of …, 2022 - Springer
The most significant genetic risk factor for developing late-onset Alzheimer's disease (AD) is
the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key …
the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key …
Obesity accelerates Alzheimer-related pathology in APOE4 but not APOE3 mice
VA Moser, CJ Pike - eneuro, 2017 - eneuro.org
Alzheimer's disease (AD) risk is modified by both genetic and environmental risk factors,
which are believed to interact to cooperatively modify pathogenesis. Although numerous …
which are believed to interact to cooperatively modify pathogenesis. Although numerous …