Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which, upon absorption by the host …

Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which upon absorption by the host …

Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane
signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are …

BACKGROUND & AIMS: Nonalcoholic fatty liver disease affects up to 30% of the US
population, but the mechanisms underlying this condition are incompletely understood. We …

Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here,
we assessed the impact of gut microbial choline metabolism on bacterial fitness and host …

Gut microbiota metabolization of dietary choline may promote atherosclerosis through
trimethylamine (TMA), which is rapidly absorbed and converted in the liver to proatherogenic …

Background: Trimethylamine-N-oxide (TMAO), a choline-derived gut microbiota-dependent
metabolite, is a newly recognized risk marker for cardiovascular disease. We sought to …

Highlights•Diet-driven changes in microbially produced SCFA can influence health via
signalling.•Gut microbiota mediates the release and transformation of many bioactive …

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Elucidation of the molecular mechanisms underlying the human gut microbiota's effects on
health and disease has been complicated by difficulties in linking metabolic functions …