Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …
The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)
Research examining the association between exposure to a wide range of adverse
childhood experiences (ACEs) and accelerated biological aging in older adults is limited …
childhood experiences (ACEs) and accelerated biological aging in older adults is limited …
Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks
Objective This retrospective cross-sectional study was designed to explore whether the
experience of childhood adversity was associated with epigenetic age acceleration in mid …
experience of childhood adversity was associated with epigenetic age acceleration in mid …
Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study
Background Epigenetic mechanisms may partly explain the persistent effects of adverse
childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict …
childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict …
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of …
Background Childhood adversity is a potent determinant of health across development and
is associated with altered DNA methylation signatures, which might be more common in …
is associated with altered DNA methylation signatures, which might be more common in …
The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort
Background: Statistical models that use an individual's DNA methylation levels to estimate
their age (known as epigenetic clocks) have recently been developed, with 96% correlation …
their age (known as epigenetic clocks) have recently been developed, with 96% correlation …
Association of adverse childhood experiences with accelerated epigenetic aging in midlife
Importance Adverse childhood experiences (ACEs) are associated with the risk of poorer
health, and identifying molecular mechanisms may lay the foundation for health promotion in …
health, and identifying molecular mechanisms may lay the foundation for health promotion in …