Cells communicate with each other via receptor-ligand interactions. Here, we describe
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …

Deciphering immune recognition is critical for understanding a broad range of diseases and
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …

Novel single-cell-based technologies hold the promise of matching T cell receptor (TCR)
sequences with their cognate peptide-MHC recognition motif in a high-throughput manner …

T cell recognition of specific antigens mediates protection from pathogens and controls
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …

Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are
engineered cell-surface receptors that sense a target antigen and respond by activating T …

T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies
for viral infections and cancer. However, efficient identification of clinical candidate TCRs is …

T cells create vast amounts of diversity in the genes that encode their T cell receptors
(TCRs), which enables individual clones to recognize specific peptide–major …

Differentiation of effector and memory CD8+ T cells is accompanied by extensive changes in
the transcriptome and histone modifications at gene promoters; however, the enhancer …

Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex)
T cells. These developmental pathways are associated with distinct transcriptional and …

Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for
targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their …