A large number of cancer stem cells (CSCs) were identified and characterized; however, the
origins and formation of CSCs remain elusive. In this study, we examined the origination of …

A large number of cancer stem cells (CSCs) have been isolated and identified; however,
none has been cultured in an unlimited manner in vitro without losing tumorigenicity and …

CD34+ stem cells play an important role during liver development and regeneration. Thus,
we hypothesized that some human liver carcinomas (HLCs) might be derived from …

Background & Aims: Recent efforts in stem cell biology suggest that tumors are organized in
a hierarchy of heterogeneous cell populations and that the capability to maintain tumor …

Liver and biliary tract cancers are highly aggressive, are heterogeneous in their phenotypic
traits, and result in clinical outcomes that are difficult to manage. Cancers have …

Background Accumulating evidence supports that tumor growth and cancer relapse are
driven by cancer stem cells. Our previous work has demonstrated the existence of CD90+ …

Recent evidence suggests that a subset of hepatocellular carcinomas (HCCs) are derived
from liver cancer stem cells (LCSCs). In order to isolate and characterize LCSCs, reliable …

It is widely accepted that cancer is a disease of stem cells. Definite evidence suggests that
tumors harbor a small population of cancer stem cells (CSC) that both give rise to the bulk of …

Solid tumors are thought to contain cancer stem cells (CSCs) as a distinct population
responsible for tumor relapse and metastasis due to their abilities to self-renew, differentiate …

Increasing evidence has revealed the importance of cancer stem cells (CSCs) in
carcinogenesis. Although liver CSCs have been identified in hepatocellular carcinoma …