Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

X Wang, B Sun, Y Wang, P Gao, J Song… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-
immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) …

Th17 and Treg cells in bone related diseases

M Wang, T Tian, S Yu, N He… - Journal of Immunology …, 2013 - Wiley Online Library
Bone‐related diseases share the process of immune response that targets bone tissue and
bone marrow and then induce adverse effects on structure and function. In recent years …

The correlation between the Th17/Treg cell balance and bone health

L Zhu, F Hua, W Ding, K Ding, Y Zhang, C Xu - Immunity & Ageing, 2020 - Springer
With the ageing of the world population, osteoporosis has become a problem affecting
quality of life. According to the traditional view, the causes of osteoporosis mainly include …

Clinical immunity in bone and joints

Y Tanaka - Journal of bone and mineral metabolism, 2019 - Springer
The immune system and bone metabolism influence each other. An imbalance in the
immune system, resulting in inflammatory stimuli may induce an imbalance in bone turnover …

IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell/regulatory T cell imbalance in rheumatoid arthritis

HK Min, S Kim, JY Lee, KW Kim, SH Lee… - Journal of translational …, 2021 - Springer
Background Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18
(IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial …

The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17/regulatory Tcells in rheumatoid arthritis

T Wang, Z Wang, W Qi, G Jiang… - International Journal of …, 2023 - Wiley Online Library
Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease, having all the
hallmarks of joint swelling, joint tenderness, and progressive joint destruction, with synovitis …

Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis

F Huang, P Wong, J Li, Z Lv, L Xu… - Journal of Cellular …, 2022 - Wiley Online Library
Osteoporosis is a bone disease that is caused by disorder of the skeletal microenvironment,
and it characterized by a high disability rate and the occurrence of low energy fractures …

[HTML][HTML] Mesenchymal stem cells inhibit RANK-RANKL interactions between osteoclasts and Th17 cells via osteoprotegerin activity

KA Cho, M Park, YH Kim, KH Ryu, SY Woo - Oncotarget, 2017 - ncbi.nlm.nih.gov
Th17 cells play a critical role in several autoimmune diseases, including psoriasis and
psoriatic arthritis (PsA). Psoriasis is a chronic inflammatory skin disease associated with …

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

K Sato, A Suematsu, K Okamoto… - The Journal of …, 2006 - rupress.org
In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the
activation of T cells results in bone destruction mediated by osteoclasts, but how T cells …

Osteoimmunology: The Crosstalk between T Cells, B Cells, and Osteoclasts in Rheumatoid Arthritis

M Yang, L Zhu - International Journal of Molecular Sciences, 2024 - mdpi.com
Rheumatoid arthritis (RA) is an ongoing inflammatory condition that affects the joints and
can lead to severe damage to cartilage and bones, resulting in significant disability. This …