A major concern in cancer therapy is resistance of tumors such as glioblastoma to current
treatment protocols. Here, we report that transfer of the gene encoding second mitochondria …

We describe the synthesis and properties of a small molecule mimic of Smac, a pro-
apoptotic protein that functions by relieving inhibitor-of-apoptosis protein (IAP)–mediated …

Inhibitor of apoptosis protein (IAP) suppresses apoptosis through binding and inhibiting
active caspases-3,-7 and-9 via its baculoviral IAP repeat (BIR) domains. During apoptosis …

Smac mimetic compounds (SMC), a class of drugs that sensitize cells to apoptosis by
counteracting the activity of inhibitor of apoptosis (IAP) proteins, have proven safe in phase 1 …

In previous studies we have shown that the sensitivity of melanoma cell lines to tumor
necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis was …

Abstract The Cancer Genome Atlas (TCGA) has unveiled genomic deregulation of various
components of the extrinsic and intrinsic apoptotic pathways in different types of cancers …

Each day, the human body eliminates billions of unwanted cells by apoptotic suicide.
Apoptosis provides an important barrier against cancer; however, specific mutations enable …

The resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL)-mediated apoptosis could be overcome by treatment with subtoxic …

Hepatocellular carcinoma (HCC) displays a high resistance to tumor necrosis factor–related
apoptosis–inducing ligand (TRAIL)–mediated cell death. To increase sensitivity of HCC cells …

Recent reports suggest that a cross-talk exists between apoptosis pathways mediated by
mitochondria and cell death receptors. In the present study, we report that mitochondrial …