AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity
and associated metabolic disorders. While many factors impacting central regulation of …

The role of neuronal noncoding RNAs in energy control of the body is not fully understood.
The arcuate nucleus (ARC) of the hypothalamus comprises neurons regulating food intake …

Objective Obesity, a growing threat to the modern society, represents an imbalance of
metabolic queues that normally signal to the arcuate hypothalamic nucleus, a critical brain …

Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a
central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable …

MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of
gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched …

The hypothalamus is a crucial central nervous system area controlling appetite, body weight
and metabolism. It consists in multiple neuronal types that sense, integrate and generate …

miR-137 is a highly conserved brain-enriched microRNA (miRNA) that has been associated
with neuronal function and proliferation. Here, we show that Drosophila miR-137 null …

In obesity and type 2 diabetes, numerous genes are differentially expressed, and
microRNAs are involved in transcriptional regulation of target mRNAs, but miRNAs critically …

Obesity is a growing public health problem associated with increased risk of type 2 diabetes,
cardiovascular disease, nonalcoholic fatty liver disease (NAFLD) and cancer. Here, we …

Obesity is a growing medical and social problem worldwide. The control of energy
homeostasis in the brain is achieved by various regions including the arcuate hypothalamic …