Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in
the motor cortex, brainstem, and spinal cord. Although ALS is considered a motor neuron …

The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ)
plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal …

Background Neurodegenerative diseases are a common group of neurological disorders
characterized by progressive loss of neuronal structure and function leading to cognitive …

Background Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which
caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming …

Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are innate immunity sensors that
provide an early/effective response to pathogenic or injury conditions. We have reported that …

In the realm of Parkinson's disease (PD) research, NLRP3 inflammasome-mediated
pyroptosis has recently garnered significant attention as a potential novel form of …

The NLRP3 inflammasome signaling pathway is a major contributor to the
neuroinflammatory process in the central nervous system. Oxidative stress and …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS of
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …

Microglial NLRP3 inflammasome activation is emerging as a key contributor to
neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β …

Background Brain injury is the leading cause of death and disability in survivors of cardiac
arrest, where neuroinflammation is believed to play a pivotal role, but the underlying …