Complexities in ferret influenza virus pathogenesis and transmission models

JA Belser, AM Eckert, TM Tumpey… - … and Molecular Biology …, 2016 - Am Soc Microbiol
Ferrets are widely employed to study the pathogenicity, transmissibility, and tropism of
influenza viruses. However, inherent variations in inoculation methods, sampling schemes …

Ferreting out influenza virus pathogenicity and transmissibility: past and future risk assessments in the ferret model

JA Belser, JA Pulit-Penaloza… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
As influenza A viruses continue to jump species barriers, data generated in the ferret model
to assess influenza virus pathogenicity, transmissibility, and tropism of these novel strains …

Mapping influenza transmission in the ferret model to transmission in humans

MG Buhnerkempe, K Gostic, M Park, P Ahsan… - Elife, 2015 - elifesciences.org
The controversy surrounding'gain-of-function'experiments on high-consequence avian
influenza viruses has highlighted the role of ferret transmission experiments in studying the …

[HTML][HTML] Ferrets as models for influenza virus transmission studies and pandemic risk assessments

JA Belser, W Barclay, I Barr, RAM Fouchier… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
The ferret transmission model is extensively used to assess the pandemic potential of
emerging influenza viruses, yet experimental conditions and reported results vary among …

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

JA Belser, EHY Lau, W Barclay, IG Barr, H Chen… - Mbio, 2022 - Am Soc Microbiol
Past pandemic influenza viruses with sustained human-to-human transmissibility have
emerged from animal influenza viruses. Employment of experimental models to assess the …

[HTML][HTML] A guide for the use of the ferret model for influenza virus infection

JA Belser, AM Eckert, T Huynh, JM Gary… - The American journal of …, 2020 - Elsevier
As influenza viruses continue to jump species barriers to cause human infection,
assessments of disease severity and viral replication kinetics in vivo provide crucial …

The ferret as a model organism to study influenza A virus infection

JA Belser, JM Katz, TM Tumpey - Disease models & …, 2011 - journals.biologists.com
Influenza is a human pathogen that continues to pose a public health threat. The use of
small mammalian models has become indispensable for understanding the virulence of …

Severity of clinical disease and pathology in ferrets experimentally infected with influenza viruses is influenced by inoculum volume

IN Moore, EW Lamirande, M Paskel… - Journal of …, 2014 - Am Soc Microbiol
Ferrets are a valuable model for influenza virus pathogenesis, virus transmission, and
antiviral therapy studies. However, the contributions of the volume of inoculum administered …

Using the ferret as an animal model for investigating influenza antiviral effectiveness

DY Oh, AC Hurt - Frontiers in microbiology, 2016 - frontiersin.org
The concern of the emergence of a pandemic influenza virus has sparked an increased
effort toward the development and testing of novel influenza antivirals. Central to this is the …

Improving immunological insights into the ferret model of human viral infectious disease

J Wong, D Layton, AK Wheatley… - Influenza and Other …, 2019 - Wiley Online Library
Ferrets are a well‐established model for studying both the pathogenesis and transmission of
human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological …