The neuronal gene Arc is essential for long-lasting information storage in the mammalian
brain, mediates various forms of synaptic plasticity, and has been implicated in …

Viruses and transposable elements are major drivers of evolution and make up over half the
sequences in the human genome. In some cases, these elements are co-opted to perform …

Summary Arc/Arg3. 1 is required for synaptic plasticity and cognition, and mutations in this
gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral …

Arc is a unique immediate early gene whose expression is induced as synapses are being
modified during learning. The uniqueness comes from the fact that newly synthesized Arc …

Arc is a cellular immediate-early gene (IEG) that functions at excitatory synapses and is
required for learning and memory. We report crystal structures of Arc subdomains that form a …

Localized translation plays a crucial role in synaptic plasticity and memory consolidation.
However, it has not been possible to follow the dynamics of memory-associated mRNAs in …

Arc is an immediate early gene that is unique among neuronal mRNAs because its
transcripts are transported into dendrites and accumulate near activated synapses …

Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …

The mRNA for Arc (activity‐regulated cytoskeletal protein) is delivered into dendrites and
localizes selectively at active synapses. Here we use a green fluorescent protein‐based …

Long-lasting forms of activity-dependent synaptic plasticity involve molecular modifications
that require gene expression. Here, we describe a cellular mechanism that mediates the …