Immunosenescence and chronic inflammation associated with old age accompany brain
aging and the loss of complex behaviors. Neuroinflammation in the hippocampus plays a …

Aging is characterized by a progressive deterioration in physiological functions that is
associated with cognitive decline as well as other physical functional impairments. Microglia …

NLRP3 inflammasome is a multiprotein complex that can sense several stimuli such as
autophagy dysregulation and increased reactive oxygen species production stimulating …

Aging is accompanied by the triggering of numerous pathophysiological events, which
include inflammation, cellular senescence and the development of the senescence …

NLRP1 inflammasome has been reported to participate in many neurological disorders. Our
previous study has demonstrated that NLRP1 inflammasome is implicated in chronic stress …

Background Numerous studies have found that inhibiting the expression of NLRP3
inflammasome can significantly improve depressive-like behaviors in mice, but the research …

Background Brain aging is an important risk factor in many human diseases, such as
Alzheimer's disease (AD). The production of excess reactive oxygen species (ROS) …

Depression, regulated by central nervous system (CNS), is a significant inflammatory
disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic …

While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in
physiological cardiac aging is largely unknown. During aging, many alterations occur in the …

The gradual aging of the global population has led to a surge in age-related diseases, which
seriously threaten human health. Researchers are dedicated to understanding and coping …