Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains.
Developing improved vaccines that elicit broader immunity remains a public health priority …

Influenza virus causes acute upper and lower respiratory infections and is the most likely,
among known pathogens, to cause a large epidemic in humans. Influenza virus mutates …

Despite advancements in immunotherapeutic approaches, influenza continues to cause
severe illness, particularly among immunocompromised individuals, young children, and …

Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

The threat of novel influenza viruses emerging into the human population from animal
reservoirs, as well as the short duration of protection conferred by licensed vaccines against …

Influenza viruses are responsible for millions of cases globally and significantly threaten
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …

Background Current influenza virus vaccines are effective when well matched to the
circulating strains. Unfortunately, antigenic drift and the high diversity of potential emerging …

Current influenza vaccines are primarily targeted to induce immunity to the influenza virus
strain-specific hemagglutinin antigen and are not effective in controlling outbreaks of new …

The challenges in successful vaccination against influenza using conventional approaches
lie in their variable efficacy in different age populations, the antigenic variability of the …

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