Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6
enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype …

Abstract Cytochrome P450 2D6 (CYP2D6) is an important drug‐metabolizing enzyme
exhibiting extensive interindividual variability predominantly caused by genetic …

The metabolic activity of the polymorphic CYP2D6 enzyme is dependent on the CYP2D6
genotype; however, the guidelines for translating the genotype into phenotype, which are of …

Limited information is available on the frequency of the many CYP2D6 alleles found in
African-Americans. DNA was isolated and genetic testing was performed on samples from …

Background Although CYP2D6 has been studied extensively in differentpopulation groups,
relatively little is known for black Americans. Methods CYP2D6 activity was assessed with …

Genetic polymorphism of cytochrome P450s results in clinically significant modifications in
patients' drug metabolizing capacities. CYP2D6 has a crucial role in the elimination of …

CYP2D6 genetic polymorphisms are considered a major contributor to the large
interindividual variability in CYP2D6‐mediated drug metabolism, but fail to explain a …

The CYP2D6 gene encodes an enzyme important in the metabolism of many commonly
used medications. Variation in CYP2D6 is associated with inter-individual differences in …

CYP 2D6 participates in the biotransformation of many commonly used drugs. Large genetic
variability in CYP 2D6 results in a wide interindividual variability in the response to CYP 2D6 …

The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since
there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in …