In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

Y Song, H Yao, N Wu, J Xu, Z Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Among the current five Variants of Concern, infections caused by SARS-CoV-2 B. 1.617. 2
(Delta) variant are often associated with the greatest severity. Despite recent advances on …

In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects …

Y Furusawa, M Kiso, S Iida, R Uraki, Y Hirata, M Imai… - …, 2023 - thelancet.com
Summary Background The SARS-CoV-2 delta (B. 1.617. 2 lineage) variant was first
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …

Syndecan-4 is a key facilitator of the SARS-CoV-2 delta variant's superior transmission

A Hudák, G Veres, A Letoha, L Szilák… - International Journal of …, 2022 - mdpi.com
Emerging SARS-CoV-2 variants pose threats to vaccination campaigns against COVID-19.
Being more transmissible than the original virus, the SARS-CoV-2 B. 1.617 lineage, named …

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

B Li, A Deng, K Li, Y Hu, Z Li, Y Shi, Q Xiong… - Nature …, 2022 - nature.com
Abstract The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on
its virological profile, we here report the first local transmission of Delta in mainland China …

Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing, membrane fusion, and viral infectivity

X Jiang, Z Zhang, C Wang, H Ren, L Gao… - Signal transduction and …, 2020 - nature.com
By the end of June 2020, the pandemic of coronavirus diseases 2019 (COVID-19) had
resulted in more than 10 million individuals, all over the world, being infected with the severe …

[HTML][HTML] SARS-CoV-2 D614G variant exhibits enhanced replication ex vivo and earlier transmission in vivo

YJ Hou, S Chiba, P Halfmann, C Ehre, M Kuroda… - BioRxiv, 2020 - ncbi.nlm.nih.gov
The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating
globally, but its effects in viral pathogenesis and transmission remain unclear. We …

The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants

S Gellenoncourt, N Saunders, R Robinot… - Journal of …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained genetically
stable during the first 3 months of the pandemic, before acquiring a D614G spike mutation …

Delta variant (B. 1.617. 2) of SARS-CoV-2: Current understanding of infection, transmission, immune escape, and mutational landscape

M Bhattacharya, S Chatterjee, AR Sharma, SS Lee… - Folia microbiologica, 2023 - Springer
The Delta variant is one of the alarming variants of the SARS-CoV-2 virus that have been
immensely detrimental and a significant cause of the prolonged pandemic (B. 1.617. 2) …

Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host

H Tang, Y Shao, Y Huang, S Qiao, J An… - … and Targeted Therapy, 2023 - nature.com
As the COVID-19 epidemic proceeds, new variants of SARS-CoV-2 continue to emerge. 1
Particularly the B. 1.1. 529 (Omicron) variant emerged and spread globally, surpassing the …

High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein

R Suratekar, P Ghosh, MJM Niesen… - Molecular systems …, 2022 - embopress.org
The highly contagious Delta variant of SARS‐CoV‐2 has become a prevalent strain globally
and poses a public health challenge around the world. While there has been extensive …