Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Perlecan, a highly conserved and ubiquitous basement membrane heparan sulfate
proteoglycan, is essential for life, inasmuch as its absence results in embryonic lethality in …

Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling
events controlling migration, proliferation, and differentiation. Its control of growth factor …

The goal of this study was to discover novel partners for perlecan, a major heparan sulfate
proteoglycan of basement membranes, and to examine new interactions through which …

Perlecan is a modular heparan sulfate proteoglycan that is an intrinsic constituent of all
basement membranes and extracellular matrices. Because of its strategic position and …

Perlecan is a large multidomain heparan sulfate proteoglycan of the extracellular matrix.
Expression of this proteoglycan changes dynamically during embryo implantation and …

Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes
(BMs), in cartilage, and several other mesenchymal tissues during development. Perlecan …

Perlecan, the main proteoglycan of basement membranes and pericellular spaces, is one of
the largest single-chain polypeptides of vertebrate animals. The five modules of perlecan …

In the pre-molecular era of biochemistry, scientists assigned rather unprepossessing
physiological roles to proteoglycans: they merely provided an inert scaffolding upon which …

During tumor growth and angiogenesis there is a dynamic remodeling of tissue architecture
often accompanied by the release of extracellular matrix constituents full of biological …