Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways

SM Greenberg, BJ Bacskai… - Nature Reviews …, 2020 - nature.com
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease: Pro-CAA position statement

JAR Nicoll, M Yamada, J Frackowiak… - Neurobiology of …, 2004 - Elsevier
For the purposes of this debate here we argue the case that cerebral amyloid angiopathy
(CAA) has a direct role in the pathogenesis of Alzheimer's disease (AD). Firstly, there is a …

Pathogenesis of cerebral amyloid angiopathy

AAM Rensink, RMW de Waal, B Kremer… - Brain Research …, 2003 - Elsevier
Cerebral amyloid angiopathy (CAA) is the result of the deposition of an amyloidogenic
protein in cortical and leptomeningeal vessels. The most common type of CAA is caused by …

Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain

RO Weller, JAR Nicoll - Neurological research, 2003 - Taylor & Francis
Cerebral amyloid angiopathy (CAA) is a feature of ageing and Alzheimer's disease (AD); it is
also associated with intracerebral hemorrhage and stroke. Here, the pathogenesis of CAA …

The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets

X Qi, J Ma - Translational neurodegeneration, 2017 - Springer
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid β-protein
(Aβ) in the leptomeningeal and cortical blood vessels, which is an age-dependent risk factor …

Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

RA Fisher, JS Miners, S Love - Brain Pathology, 2022 - Wiley Online Library
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Sporadic cerebral amyloid angiopathy

J Attems, K Jellinger, DR Thal… - Neuropathology and …, 2011 - Wiley Online Library
J. Attems, K. Jellinger, DR Thal and W. Van Nostrand (2011) Neuropathology and Applied
Neurobiology37, 75–93 Sporadic cerebral amyloid angiopathy Cerebral amyloid angiopathy …

Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood‐brain barrier integrity, and angiogenesis

R Parodi‐Rullán, J Ghiso, E Cabrera, A Rostagno… - Aging …, 2020 - Wiley Online Library
Impaired clearance in the Alzheimer's Disease (AD) brain is key in the formation of Aβ
parenchymal plaques and cerebrovascular deposits known as cerebral amyloid angiopathy …

Neurovascular Pathways and Alzheimer Amyloid β‐peptide

BV Zlokovic, R Deane, J Sallstrom, N Chow… - Brain …, 2005 - Wiley Online Library
According to the prevailing amyloid cascade hypothesis, the onset and progression of a
chronic neurodegenerative condition in Alzheimer disease (AD) is initiated by the amyloid β …

Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease

EM Robbins, RA Betensky, SB Domnitz… - Journal of …, 2006 - Soc Neuroscience
Cerebral amyloid angiopathy (CAA), the deposition of cerebrovascular β-amyloid (Aβ) in the
walls of arterial vessels, has been implicated in hemorrhagic stroke and is present in most …