Type 2 diabetes has been reproducibly clustered into five subtypes with different disease
progression and risk of complications; however, etiological differences are unknown. We …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes
(T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

In recent years, the search for genetic determinants of type 2 diabetes (T2D) has changed
dramatically. Although linkage and small-scale candidate gene studies were highly …

Patients with established type 2 diabetes display both β-cell dysfunction and insulin
resistance. To define fundamental processes leading to the diabetic state, we examined the …

Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

Abstract Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …