[HTML][HTML] The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy

MR Khezri, R Varzandeh… - Cellular & Molecular …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate …

Antibody‐mediated procoagulant platelet formation in COVID‐19 is AKT dependent

L Pelzl, A Singh, J Funk, A Witzemann… - … of Thrombosis and …, 2022 - Wiley Online Library
Background Thromboembolic events are frequently reported in patients infected with the
SARS‐CoV‐2. Recently, we observed that platelets from patients with severe COVID‐19 …

[HTML][HTML] Interrelationship between COVID-19 and coagulopathy: pathophysiological and clinical evidence

B Ragnoli, B Da Re, A Galantino, S Kette… - International Journal of …, 2023 - mdpi.com
Since the first description of COVID-19 infection, among clinical manifestations of the
disease, including fever, dyspnea, cough, and fatigue, it was observed a high incidence of …

SARS‐CoV‐2 infection induces soluble platelet activation markers and PAI‐1 in the early moderate stage of COVID‐19

AO Al‐Tamimi, AM Yusuf… - International Journal …, 2022 - Wiley Online Library
Introduction Coagulation dysfunction and thromboembolism emerge as strong comorbidity
factors in severe COVID‐19. However, it is unclear when particularly platelet activation …

[HTML][HTML] Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factor

Z Eslamifar, M Behzadifard, M Soleimani… - Thrombosis journal, 2020 - Springer
Among the pathways and mediators that may be dysregulated in COVID-19 infection, there
are proinflammatory cytokines, lymphocyte apoptosis, and the coagulation cascade. Venous …

[HTML][HTML] COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness

F Du, B Liu, S Zhang - Journal of thrombosis and thrombolysis, 2021 - Springer
The novel coronavirus disease (COVID-19) has become a universally prevalent infectious
disease. The causative virus of COVID-19 is severe acute respiratory syndrome coronavirus …

Coagulation disorders in COVID-19: role of toll-like receptors

I Biswas, GA Khan - Journal of Inflammation Research, 2020 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world.
The range of the disease is broad but among hospitalized patients with COVID-19 are …

[HTML][HTML] The most important biomarker associated with coagulation and inflammation among COVID-19 patients

LZ Hong, ZX Shou, DM Zheng, X Jin - Molecular and Cellular Biochemistry, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) induced by SARS-Cov-2 can be related to
coagulopathy. Also, the infection-induced inflammatory changes are found in patients with …

[HTML][HTML] Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

[HTML][HTML] Thrombotic mechanism involving platelet activation, hypercoagulability and hypofibrinolysis in coronavirus disease 2019

H Wada, K Shiraki, H Shimpo, M Shimaoka… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) has spread, with thrombotic complications being
increasingly frequently reported. Although thrombosis is frequently complicated in septic …