Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …

The endothelium takes part in the regulation of numerous physiological functions and lies at
the interface of circulating blood and the vessel wall. Under physiological conditions, it is …

Endothelial damage contributes to organ failure and mortality in sepsis, but the extent of the
contribution remains poorly quantified. Here, we examine the association between …

Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …

Sepsis is the leading cause of mortality in critically ill patients. In this pathological syndrome,
septic shock and sequential multiple organ failure correlate with poor outcome. The …

The endothelium is an active tissue that plays a pivotal role in maintaining cardiovascular
homeostasis. The endothelium ensures the quality of both the global and microcirculation. It …

Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate
of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates …

Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the
key factor in the progression from sepsis to organ failure. Endothelial functions affected by …

Sepsis can be defined as a phenomenon related to the host's response to infection. Sepsis
is considered an uncontrolled, unregulated, and self-sustaining intravascular inflammation …

The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological
functions, including the control of vascular tone, the movement of cells and nutrients, the …