Sex-, age-, and race/ethnicity-dependent variations in drug-processing and NRF2-regulated genes in human livers
J Liu, JY Cui, YF Lu, JC Corton, CD Klaassen - Drug Metabolism and …, 2021 - ASPET
Individual variations in xenobiotic metabolism affect the sensitivity to diseases. In this study,
the impacts of sex, age, and race/ethnicity on drug-processing genes and nuclear factor …
the impacts of sex, age, and race/ethnicity on drug-processing genes and nuclear factor …
The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers
A Anwar-Mohamed, OS Degenhardt, MAM El Gendy… - Toxicology in Vitro, 2011 - Elsevier
Previous reports have proposed a cross-talk between the nuclear factor erythroid-2 p45-
related factor-2 (Nrf2)/antioxidant response element (ARE) and the aryl hydrocarbon …
related factor-2 (Nrf2)/antioxidant response element (ARE) and the aryl hydrocarbon …
Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver
KC Wu, JY Cui, CD Klaassen - PloS one, 2012 - journals.plos.org
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery
of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH …
of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH …
Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
LM Aleksunes, CD Klaassen - Drug Metabolism and Disposition, 2012 - ASPET
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor
(CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α (PPARα) …
(CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α (PPARα) …
Disease, drug metabolism, and transporter interactions
JL Staudinger - Pharmaceutical research, 2013 - Springer
Drug metabolism is a highly complex process involving the cooperative function of drug
transporter proteins and drugconjugating and-metabolizing enzymes, as well as targeted …
transporter proteins and drugconjugating and-metabolizing enzymes, as well as targeted …
Expression of constitutive androstane receptor, hepatic nuclear factor 4α, and P450 oxidoreductase genes determines interindividual variability in basal expression …
M Wortham, M Czerwinski, L He, A Parkinson… - Drug Metabolism and …, 2007 - ASPET
Identification of genetic variation predictive of clearance rate of a wide variety of prescription
drugs could lead to cost-effective personalized medicine. Here we identify regulatory genes …
drugs could lead to cost-effective personalized medicine. Here we identify regulatory genes …
Regulation of drug transporters by the farnesoid X receptor in mice
T Maeda, M Miyata, T Yotsumoto… - Molecular …, 2004 - ACS Publications
The farnesoid X receptor (FXR, NR1H4) regulates bile acid and lipid homeostasis by acting
as an intracellular bile acid-sensing transcription factor, resulting in altered expression of …
as an intracellular bile acid-sensing transcription factor, resulting in altered expression of …
Sex-and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes
Y Uno, R Takata, G Kito, H Yamazaki… - Drug Metabolism and …, 2017 - Elsevier
Sex and age differences in hepatic expression of drug-metabolizing enzyme genes could
cause variations in drug metabolism, but has not been fully elucidated, especially in Asian …
cause variations in drug metabolism, but has not been fully elucidated, especially in Asian …
Beyond CAR and PXR
SG Dixit, RG Tirona, RB Kim - Current drug metabolism, 2005 - ingentaconnect.com
It is becoming increasingly evident that constitutive, induced, and regulated expression of
genes important to the drug disposition process such as drug transporters, phase I and II …
genes important to the drug disposition process such as drug transporters, phase I and II …
Co-expression of drug metabolizing cytochrome P450 enzymes and estrogen receptor alpha (ESR1) in human liver: racial differences and the regulatory role of ESR1
JM Collins, D Wang - Drug metabolism and personalized therapy, 2021 - degruyter.com
Objectives The function and expression of cytochrome P450 (CYP) drug metabolizing
enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The …
enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The …