Severe malaria is associated with parasite binding to endothelial protein C receptor
Sequestration of Plasmodium falciparum-infected erythrocytes in host blood vessels is a key
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …
The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum …
By attaching infected erythrocytes to the vascular lining, Plasmodium falciparum parasites
leave blood circulation and avoid splenic clearance. This sequestration is central to …
leave blood circulation and avoid splenic clearance. This sequestration is central to …
Interaction between endothelial protein C receptor and intercellular adhesion molecule 1 to mediate binding of Plasmodium falciparum-infected erythrocytes to …
ABSTRACT Intercellular adhesion molecule 1 (ICAM-1) and the endothelial protein C
receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria …
receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria …
PECAM-1/CDS31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes
CJ Treutiger, A Heddini, V Fernandez, WA Muller… - Nature medicine, 1997 - nature.com
Excessive binding of Plasmodium falciparum-infected red blood cells (pRBCs) to the
vascular endothelium (cytoadherence) and to uninfected erythrocytes (rosetting) may lead to …
vascular endothelium (cytoadherence) and to uninfected erythrocytes (rosetting) may lead to …
Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum
AR Berendt, DL Simmons, J Tansey, CI Newbold… - Nature, 1989 - nature.com
THE primary event in the pathogenesis of severe malaria in Plasmodium falciparum
infection is thought fo be adherence of trophozoite-and schizont-infected erythrocytes to …
infection is thought fo be adherence of trophozoite-and schizont-infected erythrocytes to …
Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass
The interplay between cellular and molecular determinants that lead to severe malaria in
adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult …
adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult …
Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1
N Tuikue Ndam, A Moussiliou… - The Journal of …, 2017 - academic.oup.com
Background. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …
[HTML][HTML] Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria
The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and
must retain the ability to bind to host receptors while also diversifying to aid immune evasion …
must retain the ability to bind to host receptors while also diversifying to aid immune evasion …
Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes
A common pathological characteristic of Plasmodium falciparum infection is the
cytoadhesion of mature-stage-infected erythrocytes (IE) to host endothelium and …
cytoadhesion of mature-stage-infected erythrocytes (IE) to host endothelium and …
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains
Most severe Plasmodium falciparum infections are experienced by young children. Severe
symptoms are precipitated by vascular sequestration of parasites expressing a particular …
symptoms are precipitated by vascular sequestration of parasites expressing a particular …