The proliferative capacity and continuous survival of cells are highly dependent on
telomerase expression and the maintenance of telomere length. For this reason, elevated …

Telomerase expression and telomere maintenance are critical for cell proliferation and
survival, and they play important roles in development and cancer, including hematological …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Human telomerase is a nuclear ribonucleoprotein enzyme complex that catalyzes the
synthesis and extension of telomeric DNA. This enzyme is highly expressed and active in …

Telomerase activity and telomere elongation are essential conditions for the unlimited
proliferation of neoplastic cells. Point mutations in the core promoter region of the …

Telomerase activation is observed in almost 90% of human cancers but not in normal
tissues of somatic origin and thus is a critical step for multistep carcinogenesis. A more …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

Telomerase is the enzyme required for the addition of telomeric repeats to the ends of
chromosomes and thus for chromosome stability. Most somatic human cells lack telomerase …

Telomere attrition limits the replicative potential of most somatic cells. In contrast, tumor cells
acquire immortality by continuous telomere maintenance which is predominantly due to the …

Malignant transformation from mortal, normal cells to immortal, cancer cells is generally
associated with activation of telomerase and subsequent telomere maintenance. A major …