For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity
varies considerably across healthy older individuals, and is suggested to contribute to …

Leading a mentally stimulating life may build up a reserve of neural and mental resources
that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and
behavioral function, may play an important role healthy ageing and in neurodegenerative …

Introduction The locus coeruleus (LC) undergoes extensive neurodegeneration in early
Alzheimer's disease (AD). The LC is implicated in regulating the sleep–wake cycle …

The locus coeruleus (LC) plays a crucial role in modulating several higher order cognitive
functions via its widespread projections to the entire brain. We set out to investigate the …

There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC)
is important for later-life cognition. Less understood is how LC integrity relates to brain …