A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …

The health of organisms and cells depends on appropriate responses to diverse internal
and external cues, stimuli, or challenges, such as changes in hormone or cytokine levels, or …

The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

Cell signalling engenders cells with the capability to receive and process information from
the intracellular and extracellular environments, trigger and execute biological responses …

Animal cells use a conserved repertoire of intercellular signaling pathways to communicate
with one another. These pathways are well-studied from a molecular point of view. However …

Proteins mediate transmission of signals along intercellular and intracellular pathways and
between the exterior and the interior of a cell. The dynamic properties of signaling proteins …

Intracellular signaling pathways that share common components often elicit distinct
physiological responses. In most cases, the biochemical mechanisms responsible for this …

Signaling pathways come together to form networks that connect receptors to many different
cellular machines. Such networks not only receive and transmit signals but also process …

Signal transduction networks allow eukaryotic cells to make decisions based on information
about intracellular state and the environment. Biochemical noise significantly diminishes the …

A ubiquitous building block of signaling pathways is a cycle of covalent modification (eg,
phosphorylation and dephosphorylation in MAPK cascades). Our paper explores the kind of …