Structure and function of the blood–brain barrier (BBB)

F Benz, S Liebner - Physiology, Pharmacology and Pathology of the Blood …, 2020 - Springer
The blood-brain barrier (BBB) protects the vertebrate central nervous system from harmful
blood-borne, endogenous and exogenous substances to ensure proper neuronal function …

The molecular constituents of the blood–brain barrier

BW Chow, C Gu - Trends in neurosciences, 2015 - cell.com
The blood–brain barrier (BBB) maintains the optimal microenvironment in the central
nervous system (CNS) for proper brain function. The BBB comprises specialized CNS …

The evolving concept of the blood brain barrier (BBB): from a single static barrier to a heterogeneous and dynamic relay center

A Villabona-Rueda, C Erice, CA Pardo… - Frontiers in Cellular …, 2019 - frontiersin.org
The blood–brain barrier (BBB) helps maintain a tightly regulated microenvironment for
optimal central nervous system (CNS) homeostasis and facilitates communications with the …

The blood–brain barrier in health and disease

R Daneman - Annals of neurology, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

Functional morphology of the blood–brain barrier in health and disease

S Liebner, RM Dijkhuizen, Y Reiss, KH Plate… - Acta …, 2018 - Springer
The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

[PDF][PDF] Breaking and building the wall: the biology of the blood-brain barrier in health and disease

A Keller - Swiss medical weekly, 2013 - smw.ch
The blood-brain barrier (BBB) is a complex feature of brain endothelial cells that restricts the
passage of blood-borne molecules into the brain parenchyma, while ensuring the delivery of …

Wnt/β-catenin signaling controls development of the blood–brain barrier

S Liebner, M Corada, T Bangsow, J Babbage… - The Journal of cell …, 2008 - rupress.org
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is
indispensable for fluid homeostasis and neuronal function. In this study, we show that …

Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches

FL Cardoso, D Brites, MA Brito - Brain research reviews, 2010 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

The dynamic blood–brain barrier

J Keaney, M Campbell - The FEBS journal, 2015 - Wiley Online Library
With the endothelium as its central unit, the blood–brain barrier (BBB) is a complex
multicellular structure separating the central nervous system (CNS) from the systemic …

Cells of the blood–brain barrier: an overview of the neurovascular unit in health and disease

HL McConnell, A Mishra - The Blood-Brain Barrier: Methods and Protocols, 2022 - Springer
The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …