Aliskiren attenuates the inflammatory response and wound healing process in diabetic mice with periodontal disease

SHP Oliveira, VGB Brito, SCT Frasnelli… - Frontiers in …, 2019 - frontiersin.org
The aim of this study was to characterize the role of local RAS (renin–angiotensin system) in
the inflammatory response of normal (N) and diabetic (D) mice with periodontal disease …

Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system

K Yan, Y Shen - Molecular medicine reports, 2017 - spandidos-publications.com
The local renin-angiotensin system (RAS) has been reported to have an important role in the
pathogenesis and progression of metabolic bone diseases, including osteoarthritis (OA) …

Silibinin alleviates inflammation‐induced bone loss by modulating biological interaction between human gingival fibroblasts and monocytes

RY Huang, HY Chang, SM Chih, TV Dyke… - Journal of …, 2023 - Wiley Online Library
Background Silibinin has shown various pharmacological effects that could be attributed to
its antioxidant, anti‐inflammatory, and immunoregulatory properties. However, the …

The anti-inflammatory effect of different doses of aliskiren in rat models of inflammation

TA Aziz, AA Kareem, HH Othman… - Drug Design …, 2020 - Taylor & Francis
Objective The present study was designed to evaluate the anti-inflammatory effects of
different doses of aliskiren in two animal models of inflammation. Methodology Sixty-six …

AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, blocks inflammatory mediators, and upregulates antioxidant enzymes and …

TJ Dionísio, GP Souza… - Journal of …, 2020 - Wiley Online Library
Background The initiation and progression of periodontitis might involve a local renin‐
angiotensin system in periodontal tissue. This study hypothesized that Losartan treatment …

Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model

AA Araújo, H Varela, GAC Brito, CACX Medeiros… - PLoS …, 2014 - journals.plos.org
Aims The aim of this study was to evaluate the effects of azilsartan (AZT) on bone loss,
inflammation, and the expression of matrix metallo proteinases (MMPs), receptor activator of …

Downregulation of lncRNA ANRIL Inhibits Osteogenic Differentiation of Periodontal Ligament Cells via Sponging miR‐7 through NF‐κB Pathway

X Liu, Y Zhou - Analytical Cellular Pathology, 2021 - Wiley Online Library
Background. Long noncoding RNAs (lncRNAs) are dysregulated in periodontitis
development and involved in osteogenesis. The current study was aimed at investigating the …

Gastrodin attenuates lipopolysaccharide‑induced inflammation and oxidative stress, and promotes the osteogenic differentiation of human periodontal ligament stem …

Q Feng - Experimental and Therapeutic Medicine, 2022 - spandidos-publications.com
Periodontitis is a common inflammatory gum disease that destroys the periodontal tissue.
Gastrodin (GAS) is the predominant bioactive component of Gastrodia elata Blume and …

Retracted: Expression of angiotensin II and its receptors in cyclosporine‐induced gingival overgrowth

T Subramani, K Senthilkumar… - Journal of Periodontal …, 2013 - Wiley Online Library
Background and Objectives The renin–angiotensin system (RAS) is considered as a
hormonal circulatory system involved in maintaining blood pressure, electrolyte and fluid …

Functional local renin-angiotensin system in human and rat periodontal tissue

CF Santos, AC Morandini, TJ Dionísio, FA Faria… - PloS one, 2015 - journals.plos.org
The initiation or progression of periodontitis might involve a local renin-angiotensin system
(RAS) in periodontal tissue. The aim of this study was to further characterize the local RAS in …