Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Our understanding of the roles played by zinc in the physiological and pathological
functioning of the brain is rapidly expanding. The increased availability of genetically …

Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in
cellular biology. It is required for normal mammalian brain development and physiology …

The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology.
The recent development of powerful tools, including zinc-sensitive fluorescent probes …

The trace metal zinc is a biofactor that plays essential roles in the central nervous system
across the lifespan from early neonatal brain development through the maintenance of brain …

In addition to its familiar role as a component of metalloproteins, zinc is also sequestered in
the presynaptic vesicles of a specialized type of neurons calledzinc-containing'neurons …

Zinc is abundant in the brain, having, after iron, the highest concentration among all
transition metals. Most of this brain zinc (90%) is bound up in metal–protein complexes, such …

Zinc is an essential trace element, whose importance to the function of the central nervous
system (CNS) is increasingly being appreciated. Alterations in zinc dyshomeostasis has …

The vesicles of certain glutamatergic terminals in the mammalian forebrain are replete with
ionic zinc. It is believed that during synaptic transmission zinc is released, binds to receptors …

The brain barrier system, ie, the blood-brain and blood-cerebrospinal fluid barriers, is
important for zinc homeostasis in the brain. Zinc is supplied to the brain via both barriers. A …