CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis

J Zhou, JL Pathak, T Cao, B Chen, W Wei, S Hu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Sjögren's syndrome (SS) is a chronic autoimmune disease that predominantly
affects exocrine glands. Previous studies have demonstrated that upregulated interferon …

Identification of Key Genes for Pyroptosis-Induced Salivary Gland Inflammation in Sjogren's Syndrome Based on Microarray Data and Immunohistochemistry Analysis

K Zhang, Z Luo, X Zhu, X Yao, D Lu… - Journal of …, 2023 - Taylor & Francis
Purpose Sjogren's Syndrome (SS) is a systemic autoimmune disease primarily
characterized by dysfunction of the exocrine glands. Research into the etiology and …

[HTML][HTML] Identification of ferroptosis-related diagnostic markers in primary Sjögren's syndrome based on machine learning

H Yang, C Sun, X Wang, T Wang, C Xie… - Medicina Oral, Patología …, 2024 - ncbi.nlm.nih.gov
Background Primary Sjogren's syndrome (pSS) is a common autoimmune disorder that
affects up to 0.3-3% of the global population. Ferroptosis has recently been identified to play …

Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren's syndrome-like autoimmune disease

A Okuma, K Hoshino, T Ohba, S Fukushi, S Aiba… - Immunity, 2013 - cell.com
Sjögren's syndrome (SS) is an autoimmune disease characterized by exocrinopathy that
leads to dry eye and mouth. Although lymphocyte infiltration into exocrine glands and the …

Phosphorylated signal transducer and activator of transcription proteins 1 in salivary glandular tissue: an important histological marker for diagnosis of primary …

Q Zheng, L Liu, B Wang, Y He, M Zhang, G Shi - RMD open, 2023 - rmdopen.bmj.com
Objectives The pathological diagnostic criteria for primary Sjögren's syndrome (SjS) have
certain limitations. We first explored the key pathogenic pathways of SjS through a …

Bioinformatics analysis identified immune infiltration, risk and drug prediction models of copper-induced death genes involved in salivary glands damage of primary …

N Zhang, C Ji, X Peng, M Tang, X Bao, C Yuan - Medicine, 2022 - journals.lww.com
This study aimed to identify copper-induced death genes in primary Sjögren's syndrome
(pSS) and explore immune infiltration, risk and drug prediction models for salivary glands …

In Sjögren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation

MM Varin, T Guerrier, V Devauchelle-Pensec… - Autoimmunity …, 2012 - Elsevier
Sjögren's syndrome (SS) is a chronic autoimmune epithelitis associated with diffuse
lymphocytic infiltration that varies in composition and differs according to lesion severity. T …

[HTML][HTML] Leptin/OB-R pathway promotes IL-4 secretion from B lymphocytes and induces salivary gland epithelial cell apoptosis in Sjögren's syndrome

T Xu, W Xie, Y Ma, S Zhou, L Zhang, J Chen, M Cai… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Sjögren's syndrome (SjS) is a chronic autoimmune epithelitis in which cell apoptosis
promotes the formation of inflammatory lesions. We used immunohistochemistry and TUNEL …

Integrative analysis of transcriptome and proteome in primary Sjögren syndrome

X Qiu, B Wang, H Gong, S Bu, P Li, R Zhao, M Li, L Zhu… - Genomics, 2024 - Elsevier
Abstract Objective Primary Sjögren's syndrome (pSS) is a intricate autoimmune disease
mainly characterized of immune-mediated destruction of exocrine tissues, such as salivary …

Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS–STING signaling pathway

W Zhu, Y Wang, Y Guan, Y Lu, Y Li, L Sun… - …, 2024 - Springer
Background Sjögren's Syndrome (SS) is also known as autoimmune exocrine gland
disease. Previous studies have confirmed that adaptive immunity plays an important role in …