The importance of macrophages in adipose tissue (AT) homeostasis and inflammation is
well established. However, the potential cues that regulate their function remain …

Notch signaling has been recognized recently as a key regulator of metabolism. Here, we
determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant …

Notch signaling and nuclear receptor PPARγ are involved in macrophage polarization, but
cross talk between them has not been reported in macrophages. In this study, the effect of …

Adipose tissues, composed with mature adipocytes and preadipocytic stromal/stem cells,
play crucial roles in whole body energy metabolism and regenerative medicine. Mature …

Perivascular adipose tissue (PVAT) regulates vascular function by secreting vasoactive
substances. In mice, Notch signaling is activated in the PVAT during diet-induced obesity …

The role of the Notch signaling pathway in adipogenesis has long been controversial as the
action of individual Notch receptors appears to vary with experimental conditions. In this …

Abstract Objective The Notch family of intermembrane receptors is highly conserved across
species and is involved in cell fate and lineage control. Previous in vitro studies have shown …

Notch signaling pathways modulate various cellular processes, including cell proliferation,
differentiation, adhesion and communication. Recent studies have demonstrated that …

Background/objectives: Obesity is a pandemic disorder that is characterized by
accumulation of adipose tissue and chronic low-grade inflammation that is driven primarily …

Macrophages are a key cell type in the innate immune system, and its proinflammatory (M1)
activation in the liver plays a critical role in pathogenesis of alcoholic steatohepatitis …