Background Tripartite motif (TRIM) family proteins have more than 80 members and are
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are
critically implicated in the occurrence and development of tumors. They can function through …

The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is
known to play a dual role as both tumor suppressor and oncogene, and to function at the …

As a member of the TRIM protein family, TRIM27 is a RING-mediated E3 ubiquitin ligase that
can mark other proteins for degradation. Its ubiquitination targets include PTEN, IκBα and …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated,
but the huge heterogeneity of these diseases, to be intended both inter-and intra-tumour …

Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the
population and, as all malignant tumors, often develops resistance to chemotherapies with …

The tripartite motif (TRIM) family is defined by the presence of a Really Interesting New Gene
(RING) domain, one or two B-box motifs and a coiled-coil region. TRIM proteins play key …