Engineered extracellular vesicles and their mimetics for cancer immunotherapy

C Liu, Y Wang, L Li, D He, J Chi, Q Li, Y Wu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) are heterogeneous membranous vesicles secreted by living
cells that are involved in many physiological and pathological processes as intermediaries …

Immune cell-derived extracellular vesicles–new strategies in cancer immunotherapy

P Yang, Y Peng, Y Feng, Z Xu, P Feng, J Cao… - Frontiers in …, 2021 - frontiersin.org
Immune cell-derived extracellular vesicles (EVs) have increasingly become the focus of
research due to their unique characteristics and bioinspired applications. They are lipid …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Extracellular vesicles as an advanced delivery biomaterial for precision cancer immunotherapy

S Ruan, Z Greenberg, X Pan, P Zhuang… - Advanced …, 2022 - Wiley Online Library
In recent years, cancer immunotherapy has been observed in numerous preclinical and
clinical studies for showing benefits. However, due to the unpredictable outcomes and low …

Strategies for engineering of extracellular vesicles

AA Danilushkina, CC Emene, NA Barlev… - International journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released by cells into the extracellular
space. EVs mediate cell-to-cell communication through local and systemic transportation of …

Extracellular vesicles remodel tumor environment for cancer immunotherapy

M Yue, S Hu, H Sun, B Tuo, B Jia, C Chen, W Wang… - Molecular Cancer, 2023 - Springer
Tumor immunotherapy has transformed neoplastic disease management, yet low response
rates and immune complications persist as major challenges. Extracellular vesicles …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Modulating cytokine production via select packaging and secretion from extracellular vesicles

BJ Barnes, CC Somerville - Frontiers in Immunology, 2020 - frontiersin.org
Cytokines are soluble factors that play vital roles in systemic function due to their ability to
initiate and mediate cell-to-cell communication. Another important mechanism of …

Therapeutic prospects of extracellular vesicles in cancer treatment

DS Chulpanova, KV Kitaeva, V James… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment,
such as endothelial cells, tumor-associated fibroblasts, pericytes, and immune system cells …

Extracellular‐vesicle‐based drug delivery systems for enhanced antitumor therapies through modulating the cancer‐immunity cycle

T Yong, Z Wei, L Gan, X Yang - Advanced Materials, 2022 - Wiley Online Library
Although immunotherapy harnessing activity of the immune system against tumors has
made great progress, the treatment efficacy remains limited in most cancers. Current …