The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …

The exposure of the airway epithelium to external stimuli such as allergens, microbes, and
air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal …

The interaction between the airway epithelium and the inhaled environment is crucial to
understanding the pathobiology of asthma. Several studies have identified an important role …

Alarmins are innate cytokines, including thymic stromal lymphopoietin (TSLP), interleukin-33
(IL-33), and interleukin-25 (IL-25), which are mainly produced by airway epithelium and …

Monoclonal antibody therapies have significantly improved treatment outcomes for patients
with severe asthma; however, a significant disease burden remains. Available biologic …

Asthma is a chronic airway inflammatory disorder with characteristic symptoms of dyspnea,
wheeze, chest tightness and cough, and physiological abnormalities of variable airway …

The airway epithelium is the first line of defense for the lungs, detecting inhaled
environmental threats through pattern recognition receptors expressed transmembrane or …

Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …

The alarmin cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) play a critical
role in asthma pathogenesis by inducing mucosal Th2-type cytokine production. Although …

Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are
released upon airway epithelial injury from insults such as viruses and cigarette smoke, and …