Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract

O Kocabiyik, P Amlashi, AL Vo, H Suh… - Science …, 2024 - science.org
Viruses, bacteria, and parasites frequently cause infections in the gastrointestinal tract, but
traditional vaccination strategies typically elicit little or no mucosal antibody responses …

Nanovaccines mediated subcutis‐to‐intestine cascade for improved protection against intestinal infections

X Zhong, G Du, X Wang, Y Ou, H Wang, Y Zhu, X Hao… - Small, 2022 - Wiley Online Library
Parenteral vaccines typically can prime systemic humoral immune response, but with limited
effects on cellular and mucosal immunity. Here, a subcutis‐to‐intestine cascade for …

Nanoemulsion adjuvant augments retinaldehyde dehydrogenase activity in dendritic cells via MyD88 pathway

M Farazuddin, RR Goel, NJ Kline, JJ Landers… - Frontiers in …, 2019 - frontiersin.org
Mucosal surfaces are the primary point of entry for many infectious agents and mucosal
immune responses serve as the primary defense to these pathogens. In order to mount an …

Exploiting the Lymph-Node-Amplifying Effect for Potent Systemic and Gastrointestinal Immune Responses via Polymer/Lipid Nanoparticles

Y Du, Y Xia, Y Zou, Y Hu, J Fu, J Wu, XD Gao, G Ma - ACS nano, 2019 - ACS Publications
Parenteral vaccinations are not able to elicit effective systemic and gastrointestinal immune
protection simultaneously because the lymphocytes are typically restricted to primed tissues …

Gut-associated lymphoid tissues for the development of oral vaccines

J Kunisawa, Y Kurashima, H Kiyono - Advanced drug delivery reviews, 2012 - Elsevier
Oral vaccine has been considered to be a prospective vaccine against many pathogens
especially invading across gastrointestinal tracts. One key element of oral vaccine is …

Intestinal lymphoid tissues: is variety an asset or a liability?

RD Newberry - Current opinion in gastroenterology, 2008 - journals.lww.com
Intestinal lymphoid tissues: is variety an asset or a liabil... : Current Opinion in
Gastroenterology Intestinal lymphoid tissues: is variety an asset or a liability? : Current …

Strategies to develop a mucosa-targeting vaccine against emerging infectious diseases

F Feng, Z Wen, J Chen, Y Yuan, C Wang, C Sun - Viruses, 2022 - mdpi.com
Numerous pathogenic microbes, including viruses, bacteria, and fungi, usually infect the
host through the mucosal surfaces of the respiratory tract, gastrointestinal tract, and …

A liposome-based adjuvant containing two delivery systems with the ability to induce mucosal immunoglobulin a following a parenteral immunization

D Christensen, L Bøllehuus Hansen, R Leboux… - ACS …, 2019 - ACS Publications
Worldwide, enteric infections rank third among all causes of disease burdens, and vaccines
able to induce a strong and long-lasting intestinal immune responses are needed …

[HTML][HTML] Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization

DR Frederick, JA Goggins, LM Sabbagh, LC Freytag… - Mucosal …, 2018 - Elsevier
Infectious diarrheal diseases are the second leading cause of death in children under 5
years, making vaccines against these diseases a high priority. It is known that certain …

Isolating lymphocytes from the mouse small intestinal immune system

Z Qiu, BS Sheridan - JoVE (Journal of Visualized Experiments), 2018 - jove.com
The intestinal immune system plays an essential role in maintaining the barrier function of
the gastrointestinal tract by generating tolerant responses to dietary antigens and …