Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

S Faissner, JR Plemel, R Gold, VW Yong - Nature reviews drug …, 2019 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …

Chronic progressive multiple sclerosis-pathogenesis of neurodegeneration and therapeutic strategies

D Fitzner, M Simons - Current neuropharmacology, 2010 - ingentaconnect.com
Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating disease of the
central nervous system (CNS) that usually starts as a relapsing-remitting disease. In most …

Targets of therapy in progressive MS

H Lassmann - Multiple Sclerosis Journal, 2017 - journals.sagepub.com
Highly effective anti-inflammatory therapies have so far been developed for patients with
relapsing/remitting multiple sclerosis, which also show some benefits in the early …

Progressive multiple sclerosis: pathology and pathogenesis

H Lassmann, J Van Horssen, D Mahad - Nature Reviews Neurology, 2012 - nature.com
Major progress has been made during the past three decades in understanding the
inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS) …

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

MA Friese, B Schattling, L Fugger - Nature Reviews Neurology, 2014 - nature.com
Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Mechanisms of neurodegeneration and axonal dysfunction in progressive multiple sclerosis

J Correale, M Marrodan, MC Ysrraelit - Biomedicines, 2019 - mdpi.com
Multiple Sclerosis (MS) is a major cause of neurological disability, which increases
predominantly during disease progression as a result of cortical and grey matter structures …

Neurodegeneration in multiple sclerosis: novel treatment strategies

F Luessi, V Siffrin, F Zipp - Expert Review of Neurotherapeutics, 2012 - Taylor & Francis
In recent years it has become clear that the neuronal compartment already plays an
important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course …

Therapeutic advances and challenges in the treatment of progressive multiple sclerosis

LE Baldassari, RJ Fox - Drugs, 2018 - Springer
Despite the fact that majority of patients with multiple sclerosis (MS) have relapsing-remitting
disease, many transition to secondary progressive disease (SPMS) over time. This transition …

Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis

SS Zamvil, L Steinman - Neuron, 2003 - cell.com
Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating
disease that causes relapsing and chronic neurologic impairment. Recent observations …

Progressive multiple sclerosis: from pathogenic mechanisms to treatment

J Correale, MI Gaitán, MC Ysrraelit, MP Fiol - Brain, 2017 - academic.oup.com
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …