Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

The current view of cytoplasmic RNA-mediated innate immune signaling involves the
differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Upon recognition of specific molecular patterns on microbes, host cells trigger an innate
immune response, which culminates in the production of type I interferons, proinflammatory …

The recent, rapid progress in our understanding of cytoplasmic RNA-mediated antiviral
innate immune signaling was initiated by the discovery of retinoic acid-inducible gene I (RIG …

Antiviral innate immunity is triggered by sensing viral nucleic acids. RIG-I (retinoic acid-
inducible gene-I) is an intracellular molecule that responds to viral nucleic acids and …

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses
against viral infections that serve to limit virus replication and to stimulate adaptive immunity …

RNA virus infection is recognized by retinoic acid-inducible gene (RIG)-I–like receptors
(RLRs), RIG-I, and melanoma differentiation–associated gene 5 (MDA5) in the cytoplasm …

Highlights•RLRs recognize viral non-self RNA with differential molecular machinery.•
Cytoplasmic aggregates containing RLRs are formed in response to viral dsRNA.•Ubiquitin …

ABSTRACT RIG-I-like receptors (RLRs) play important roles in the host defense to
numerous viral pathogens. Since they were discovered, much light has been shed on the …